Article
MTHFR C677T polymorphism and anatomopathological characteristics with prognostic significance in sporadic colorectal cancer.
Pathology, research and practice - 1 Dec 2015
Delgado-Plasencia Luciano, Álvarez-Argüelles Hugo, Salido-Ruiz Eduardo, Castro-Peraza M Elisa, Bravo-Gutiérrez Alberto, Fernández-Peralta Antonia, González-Aguilera Juan, Alarcó-Hernández Antonio, Medina-Arana Vicente
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis due to its role in DNA methylation, repair and synthesis. The MTHFR C677T polymorphism is associated with decreased risk of CRC and increased sensitivity to 5-FU treatment. The present study addressed the relationship between this polymorphism and histopathological and immunohistochemical...
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