Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.

doi:10.1038/nature15540

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Article

Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.

Nature - 17 Dec 2015

Oldridge Derek A, Wood Andrew C, Weichert-Leahey Nina, Crimmins Ian, Sussman Robyn, Winter Cynthia, McDaniel Lee D, Diamond Maura, Hart Lori S, Zhu Shizhen, Durbin Adam D, Abraham Brian J, Anders Lars, Tian Lifeng, Zhang Shile, Wei Jun S, Khan Javed, Bramlett Kelli, Rahman Nazneen, Capasso Mario, Iolascon Achille, Gerhard Daniela S, Guidry Auvil Jaime M, Young Richard A, Hakonarson Hakon, Diskin Sharon J, Look A Thomas, Maris John M

Abstract excerpt

Neuroblastoma is a paediatric malignancy that typically arises in early childhood, and is derived from the developing sympathetic nervous system. Clinical phenotypes range from localized tumours with excellent outcomes to widely metastatic disease in which long-term survival is approximately 40% despite intensive therapy. A previous genome-wide association study identified common polymorphisms at the LMO1 gene...

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Identifiers

PMID: 26560027
DOI: 10.1038/nature15540
PMCID: PMC4775078

Genes

LMO1
GATA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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