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HOTTIP rs1859168 C > A polymorphism reduces neuroblastoma susceptibility in Chinese children.

European journal of pediatrics - 24 Dec 2024

Zhang Ting, Yin Huimin, Guo Jiejie, Chang Jiaming, Li Mengjia, He Jing, Zhou Chunlei

Abstract excerpt

Neuroblastoma, " a malignancy originating from neural crest cells, is most commonly diagnosed in children and adolescents. Polymorphisms within the long noncoding RNA (lncRNA) HOXA distal transcript antisense RNA (HOTTIP) are believed to have the capacity to alter an individual's susceptibility to various cancers. This study aimed to investigate the link between HOTTIP gene polymorphisms and neuroblastoma...

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PMID: 39718648
DOI: 10.1007/s00431-024-05942-4

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