Article
EpCAM based capture detects and recovers circulating tumor cells from all subtypes of breast cancer except claudin-low.
Oncotarget - 29 Dec 2015
Ring Alexander, Mineyev Neal, Zhu Weizhu, Park Emily, Lomas Chip, Punj Vasu, Yu Min, Barrak Dany, Forte Victoria, Porras Tania, Tripathy Debu, Lang Julie E
Abstract excerpt
PURPOSE: The potential utility of circulating tumor cells (CTCs) as liquid biopsies is of great interest. We hypothesized that CTC capture using EpCAM based gating is feasible for most breast cancer subtypes. RESULTS: Cancer cells could be recovered from all intrinsic subtypes of breast cancer with IE/FACS, however, claudin-low cell lines showed very low capture rates compared to the four other groups (p = 0.03)....
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