Germline Sequencing Improves Tumor-Only Sequencing Interpretation in a Precision Genomic Study of Patients With Pediatric Solid Tumor.

doi:10.1200/PO.21.00281

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Article

Germline Sequencing Improves Tumor-Only Sequencing Interpretation in a Precision Genomic Study of Patients With Pediatric Solid Tumor.

JCO precision oncology - 1 Jan 2021

Schienda Jaclyn, Church Alanna J, Corson Laura B, Decker Brennan, Clinton Catherine M, Manning Danielle K, Imamovic-Tuco Alma, Reidy Deirdre, Strand Gianna R, Applebaum Mark A, Bagatell Rochelle, DuBois Steven G, Glade-Bender Julia L, Kang Wenjun, Kim AeRang, Laetsch Theodore W, Macy Margaret E, Maese Luke, Pinto Navin, Sabnis Amit J, Schiffman Joshua D, Colace Susan I, Volchenboum Samuel L, Weiser Daniel A, Nowak Jonathan A, Lindeman Neal I, Janeway Katherine A, Crompton Brian D, Kamihara Junne

Abstract excerpt

PURPOSE: Molecular tumor profiling is becoming a routine part of clinical cancer care, typically involving tumor-only panel testing without matched germline. We hypothesized that integrated germline sequencing could improve clinical interpretation and enhance the identification of germline variants with significant hereditary risks. MATERIALS AND METHODS: Tumors from pediatric patients with high-risk,...

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PMID: 34964003
DOI: 10.1200/PO.21.00281
PMCID: PMC8710335

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