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Chlamydial Lytic Exit from Host Cells Is Plasmid Regulated

10 Nov 2015

Abstract excerpt

UNLABELLED: Chlamydia trachomatis is an obligate intracellular bacterium that is a globally important human pathogen. The chlamydial plasmid is an attenuating virulence factor, but the molecular basis for attenuation is not understood. Chlamydiae replicate within a membrane-bound vacuole termed an inclusion, where they undergo a biphasic developmental growth cycle and differentiate from noninfectious into...

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PMID: 26556273
DOI: 10.1128/mbio.01648-15

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