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Article

TargeTron inactivation of plasmid-regulated Chlamydia trachomatis CT084 results in a nonlytic phenotype.

Pathogens and disease - 17 Jan 2023

Karanovic Una, Lei Lei, Martens Craig A, Barbian Kent, McClarty Grant, Caldwell Harlan D, Yang Chunfu

Abstract excerpt

Chlamydia trachomatis is an obligate intracellular bacterium that causes blinding trachoma and sexually transmitted disease. The chlamydial plasmid is a critical virulence factor in the pathogenesis of these diseases. Plasmid gene protein 4 (Pgp4) plays a major role in chlamydial virulence by regulating the expression of both chromosomal genes and Pgp3. Despite the importance of Pgp4 in mediating lytic exit from...

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Identifiers

PMID: 37804183
DOI: 10.1093/femspd/ftad026
PMCID: PMC10589100

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