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Requirement of GrgA for Chlamydia infectious progeny production, optimal growth, and efficient plasmid maintenance

19 Dec 2023

Abstract excerpt

ABSTRACT Chlamydia , an obligate intracellular bacterial pathogen, has a unique developmental cycle involving the differentiation of invading elementary bodies (EBs) to noninfectious reticulate bodies (RBs), replication of RBs, and redifferentiation of RBs into progeny EBs. Progression of this cycle is regulated by three sigma factors, which direct the RNA polymerase to their respective target gene promoters. We...

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PMID: 38112466
DOI: 10.1128/mbio.02036-23

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