Article
Cytokinesis is blocked in mammalian cells transfected with Chlamydia trachomatis gene CT223.
BMC microbiology - 5 Jan 2009
Alzhanov Damir T, Weeks Sara K, Burnett Jeffrey R, Rockey Daniel D
Abstract excerpt
BACKGROUND: The chlamydiae alter many aspects of host cell biology, including the division process, but the molecular biology of these alterations remains poorly characterized. Chlamydial inclusion membrane proteins (Incs) are likely candidates for direct interactions with host cell cytosolic proteins, as they are secreted to the inclusion membrane and exposed to the cytosol. The inc gene CT223 is one of a...
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