Organ fibrosis: beyond collagen I expression. Fibroblast phenotype and basement membrane proteins.

Abstract excerpt

The prevalence of fibrotic disease and its contribution to organ failure have wide-ranging consequences in terms of both morbidity and mortality and are particularly relevant in chronic conditions that afflict aging populations. The paucity of treatment options for those with fibrosis-dependent complications illustrates the challenge and underlying complexity of controlling and reducing extracellular matrix (ECM)...

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