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Article

Genetic variants in the transcription regulatory region of MEGF10 are associated with autism in Chinese Han population.

Scientific reports - 23 May 2017

Wu Zhiliu, Qin Jian, You Yang, Ma Yuanlin, Jia Meixiang, Wang Linyan, Lu Tianlan, Yue Weihua, Ruan Yanyan, Zhang Dai, Li Jun, Wang Lifang

Abstract excerpt

Multiple epidermal growth factor-like-domains 10 (MEGF10), a critical member of the apoptotic engulfment pathway, mediates axon pruning and synapse elimination during brain development. Previous studies indicated that synaptic pruning deficit was associated with autism-related phenotypes. However, the relationship between MEGF10 and autism remains poorly understood. Disease-associated variants are significantly...

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Identifiers

PMID: 28536440
DOI: 10.1038/s41598-017-02348-1
PMCID: PMC5442155

Genes

MEGF10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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