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Article

Genomic rearrangements involving programmed death ligands are recurrent in primary mediastinal large B-cell lymphoma.

Blood - 27 Mar 2014

Twa David D W, Chan Fong Chun, Ben-Neriah Susana, Woolcock Bruce W, Mottok Anja, Tan King L, Slack Graham W, Gunawardana Jay, Lim Raymond S, McPherson Andrew W, Kridel Robert, Telenius Adele, Scott David W, Savage Kerry J, Shah Sohrab P, Gascoyne Randy D, Steidl Christian

Abstract excerpt

The pathogenesis of primary mediastinal large B-cell lymphoma (PMBCL) is incompletely understood. Recently, specific genotypic and phenotypic features have been linked to tumor cell immune escape mechanisms in PMBCL. We studied 571 B-cell lymphomas with a focus on PMBCL. Using fluorescence in situ hybridization here, we report that the programmed death ligand (PDL) locus (9p24.1) is frequently and specifically...

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Share to B7-H1 Antigen
Share to Chromosomes, Human, Pair 9

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Gene Expression Regulation, Neoplastic

Share to In Situ Hybridization, Fluorescence

Share to Lymphoma, Large B-Cell, Diffuse

Share to Mediastinal Neoplasms

Share to Translocation, Genetic

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Identifiers

PMID: 24497532
DOI: 10.1182/blood-2013-10-535443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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