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Article

Detectable FLT3-ITD or RAS mutation at the time of transformation from MDS to AML predicts for very poor outcomes.

Leukemia research - 1 Dec 2015

Badar Talha, Patel Keyur P, Thompson Philip A, DiNardo Courtney, Takahashi Koichi, Cabrero Monica, Borthakur Gautam, Cortes Jorge, Konopleva Marina, Kadia Tapan, Bohannan Zach, Pierce Sherry, Jabbour Elias J, Ravandi Farhad, Daver Naval, Luthra Raja, Kantarjian Hagop, Garcia-Manero Guillermo

Abstract excerpt

BACKGROUND: The molecular events that drive the transformation from myelodysplastic syndromes (MDS) to acute myeloid leukemia (AML) have yet to be fully characterized. We hypothesized that detection of these mutations at the time of transformation from MDS to AML may lead to poorer outcomes. METHODS: We analyzed 102 MDS patients who were admitted to our institution between 2004 and 2013, had wild-type (wt)...

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Identifiers

PMID: 26547258
DOI: 10.1016/j.leukres.2015.10.005
PMCID: PMC4822515

Genes

FLT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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