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Analyzing transformation of myelodysplastic syndrome to secondary acute myeloid leukemia using a large patient database

14 May 2012

Abstract excerpt

One-third of patients with myelodysplastic syndrome (MDS) progress to secondary acute myeloid leukemia (sAML), with its concomitant poor prognosis. Recently, multiple mutations have been identified in association with MDS-to-sAMLtransition, but it is still unclear whether all these mutations are necessary for transformation. If multiple independent mutations are required for the transformation, sAML risk should...

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PMID: 22674538
DOI: 10.1002/ajh.23257

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