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Article

FLT3 mutation and AML/ETO in a case of Myelodysplastic syndrome in transformation corroborates the two hit model of leukemogenesis.

Leukemia research - 1 Jul 2007

Pinheiro Ronald Feitosa, Moreira Eloisa de Sá, Silva Maria Regina Régis, Greggio Bárbara, Alberto Fernando Lopes, Chauffaille Maria de Lourdes L F

Abstract excerpt

The aim of this report is to present a case of Myelodysplastic syndrome (MDS) who presented, during AML transformation, a step-wise genetic progression that corroborates the two hit model of leukemogenesis. A RCDM-RS (WHO)/RARS (FAB) patient with normal karyotype at diagnosis, evolved into AML after six months of follow up. At transformation, AML/ETO fusion was detected, although marrow blast cells were not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 2 Subunit

Share to fms-Like Tyrosine Kinase 3

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Share to Oncogene Proteins, Fusion

Share to RUNX1 Translocation Partner 1 Protein

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Source

Identifiers

PMID: 17079011
DOI: 10.1016/j.leukres.2006.09.018

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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