Serial determination of FLT3 mutations in myelodysplastic syndrome patients at diagnosis, follow up or acute myeloid leukaemia transformation: incidence and their prognostic significance.

doi:10.1111/j.1365-2141.2006.06171.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Serial determination of FLT3 mutations in myelodysplastic syndrome patients at diagnosis, follow up or acute myeloid leukaemia transformation: incidence and their prognostic significance.

British journal of haematology - 1 Aug 2006

Georgiou Georgios, Karali Vasiliki, Zouvelou Christina, Kyriakou Elias, Dimou Maria, Chrisochoou Stamatis, Greka Paraskevi, Dufexis Dimitrios, Vervesou Elisavet, Dimitriadou Evaggelia, Efthymiou Anna, Petrikkos Loizos, Dima Katerina, Lilakos Konstantinos, Panayiotidis Panayiotis

Abstract excerpt

The incidence of FLT3 mutations (internal tandem duplication and Asp835) was investigated in bone marrow samples from 97 patients with myelodysplastic syndrome [(MDS); excluding cases with refractory anaemia with excess blasts in transformation] at the time of diagnosis and several time points thereafter. Three patients had FLT3 mutations at presentation. Forty-two patients progressed to acute myeloid leukaemia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to fms-Like Tyrosine Kinase 3

Share to Leukemia, Myeloid

Share to Myelodysplastic Syndromes

Share to Proportional Hazards Models

Share to Statistics, Nonparametric

Share to Survival Rate

Source

Open in PubMed

Identifiers

PMID: 16787503
DOI: 10.1111/j.1365-2141.2006.06171.x

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Serial determination of FLT3 mutations in myelodysplastic syndrome patients at diagnosis, follow up or acute myeloid leukaemia transformation: incidence and their prognostic significance.PMID 16787503Read ↗

Acquisition of FLT3 or N-ras mutations is frequently associated with progression of myelodysplastic syndrome to acute myeloid leukemia.Semantic proximity Read ↗

FLT3 mutations in myelodysplastic syndrome and chronic myelomonocytic leukemia.Semantic proximity Read ↗

Internal tandem duplication of fms-like tyrosine kinase 3 is associated with poor outcome in patients with myelodysplastic syndrome.Semantic proximity Read ↗

Detectable FLT3-ITD or RAS mutation at the time of transformation from MDS to AML predicts for very poor outcomes.Semantic proximity Read ↗

FLT3 and NPM1 mutations in myelodysplastic syndromes: Frequency and potential value for predicting progression to acute myeloid leukemia.Semantic proximity Read ↗

Low frequency of FLT3 gene internal tandem duplication and activating loop mutation in therapy-related acute myelocyticleukemia and myelodysplastic syndrome.Semantic proximity Read ↗

Prognostic impact of RAS mutations in patients with myelodysplastic syndrome.Semantic proximity Read ↗

FLT3 mutations in myeloid sarcoma.Semantic proximity Read ↗

Only particular cytogenetic events are related to disease progression in sequential cytogenetic studies in myelodysplastic syndromes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.