Article
Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2.
Cancer discovery - 1 Dec 2013
O'Connell Michael P, Marchbank Katie, Webster Marie R, Valiga Alexander A, Kaur Amanpreet, Vultur Adina, Li Ling, Herlyn Meenhard, Villanueva Jessie, Liu Qin, Yin Xiangfan, Widura Sandy, Nelson Janelle, Ruiz Nivia, Camilli Tura C, Indig Fred E, Flaherty Keith T, Wargo Jennifer A, Frederick Dennie T, Cooper Zachary A, Nair Suresh, Amaravadi Ravi K, Schuchter Lynn M, Karakousis Giorgos C, Xu Wei, Xu Xiaowei, Weeraratna Ashani T
Abstract excerpt
UNLABELLED: An emerging concept in melanoma biology is that of dynamic, adaptive phenotype switching, where cells switch from a highly proliferative, poorly invasive phenotype to a highly invasive, less proliferative one. This switch may hold significant implications not just for metastasis, but also for therapy resistance. We demonstrate that phenotype switching and subsequent resistance can be guided by changes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.