Article
A Novel Approach to Evaluating Cancer Driver Gene Mutation Densities: Cytoskeleton-related Gene Candidates.
Cancer genomics & proteomics - 1 Jan 2000
Fawcett Timothy J, Parry Michele L, Blanck George
Abstract excerpt
BACKGROUND: Oncoprotein genes are over-represented in statically defined, low mutation-frequency fractions of cancer genome atlas (TCGA) datasets, consistent with a higher driver mutation density. MATERIALS AND METHODS: We developed a "continuously variable fraction" (CVF) approach to defining high and low mutation-frequency groups. RESULTS AND CONCLUSION: Using the CVF approach, an oncoprotein set was shown to...
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