Article
The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.
Genes, chromosomes & cancer - 1 Feb 2016
Gooskens Saskia L, Kenny Colin, Lazaro Antonio, O'Meara Elaine, van Tinteren Harm, Spreafico Filippo, Vujanic Gordan, Leuschner Ivo, Coulomb-L'Herminé Aurore, Perotti Daniela, de Camargo Beatriz, Bergeron Christophe, Acha García Tomas, Tanaka Mio, Pieters Rob, Pritchard-Jones Kathy, Graf Norbert, van den Heuvel-Eibrink Marry M, O'Sullivan Maureen J
Abstract excerpt
Clear cell sarcoma of the kidney (CCSK) although uncommon, is the second most frequent renal malignancy of childhood. Until now, the sole recurrent genetic aberration identified in CCSKs is t(10;17)(q22;p13), which gives rise to a fusion transcript of YWHAE and NUTM2B/E. So far, the clinical relevance of this fusion transcript is unknown. The aim of this descriptive study was to determine the clinical phenotype...
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