Article
Biophysical Studies of Bacterial Topoisomerases Substantiate Their Binding Modes to an Inhibitor.
Biophysical journal - 3 Nov 2015
Kang CongBao, Li Yan, Cherian Joseph, Liu Boping, Ng Hui Qi, Lee Michelle Yueqi, Binte Ahmad Nur Huda, Poh Zhi Ying, Wong Yun Xuan, Huang Qiwei, Wong Ying Lei, Hung Alvin W, Hill Jeffrey, Keller Thomas H
Abstract excerpt
Bacterial DNA topoisomerases are essential for bacterial growth and are attractive, important targets for developing antibacterial drugs. Consequently, different potent inhibitors that target bacterial topoisomerases have been developed. However, the development of potent broad-spectrum inhibitors against both Gram-positive (G(+)) and Gram-negative (G(-)) bacteria has proven challenging. In this study, we carried...
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