Article
Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster.
Nature communications - 18 Feb 2015
Dobson Adam J, Chaston John M, Newell Peter D, Donahue Leanne, Hermann Sara L, Sannino David R, Westmiller Stephanie, Wong Adam C-N, Clark Andrew G, Lazzaro Brian P, Douglas Angela E
Abstract excerpt
Animals bear communities of gut microorganisms with substantial effects on animal nutrition, but the host genetic basis of these effects is unknown. Here we use Drosophila to demonstrate substantial among-genotype variation in the effects of eliminating the gut microbiota on five host nutritional indices (weight, protein, lipid, glucose and glycogen contents); this includes variation in both the magnitude and...
Topics
- Animals
- Drosophila melanogaster
- Gastrointestinal Tract
- Genetic Association Studies
- Genetic Variation
- Genotype
- Glucose
- Glycogen
- Lipids
- Microbiota
- Mutation
- Nutritional Physiological Phenomena
- Phenotype