Article
Genetic variation in metallothionein and metal-regulatory transcription factor 1 in relation to urinary cadmium, copper, and zinc.
Toxicology and applied pharmacology - 15 Dec 2015
Adams Scott V, Barrick Brian, Christopher Emily P, Shafer Martin M, Makar Karen W, Song Xiaoling, Lampe Johanna W, Vilchis Hugo, Ulery April, Newcomb Polly A
Abstract excerpt
BACKGROUND: Metallothionein (MT) proteins play critical roles in the physiological handling of both essential (Cu and Zn) and toxic (Cd) metals. MT expression is regulated by metal-regulatory transcription factor 1 (MTF1). Hence, genetic variation in the MT gene family and MTF1 might influence excretion of these metals. METHODS: 321 women were recruited in Seattle, WA and Las Cruces, NM and provided demographic...
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