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Article

Metallothionein MT2A A-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jul 2016

Hattori Yuta, Naito Mariko, Satoh Masahiko, Nakatochi Masahiro, Naito Hisao, Kato Masashi, Takagi Sahoko, Matsunaga Takashi, Seiki Toshio, Sasakabe Tae, Suma Shino, Kawai Sayo, Okada Rieko, Hishida Asahi, Hamajima Nobuyuki, Wakai Kenji

Abstract excerpt

Metallothioneins (MTs) are proteins that protect cells from toxic agents such as heavy metal ions or reactive oxygen species. MT2A A-5G is a single nucleotide polymorphism in the promoter region of the MT2A gene, and the minor G allele results in lower transcription efficiency. We aimed to elucidate associations between MT2A A-5G and risks of 2 diseases potentially related to lowered MT expression, chronic kidney...

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Identifiers

PMID: 27122239
DOI: 10.1093/toxsci/kfw080
PMCID: PMC4922544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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