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Article

Quantitative analysis of anti-hepatitis C virus antibody-secreting B cells in patients with chronic hepatitis C.

Hepatology (Baltimore, Md.) - 1 Jan 2006

Umemura Takeji, Wang Richard Y-H, Schechterly Cathy, Shih J Wai-Kuo, Kiyosawa Kendo, Alter Harvey J

Abstract excerpt

To investigate the quantitative characteristics of humoral immunity in patients with hepatitis C, we established an enzyme-linked immunosorbent spot (ELISpot) assay for detection of anti-hepatitis C virus (HCV)-secreting B cells. Receiver operating characteristic curve analysis demonstrated 100% specificity and 58% to 92% sensitivity for detecting B-cell responses to NS5b, NS3, E2, and core antigens. The median...

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Identifiers

PMID: 16323211
DOI: 10.1002/hep.20917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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