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Article

Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance.

Nature genetics - 1 Jan 2015

Davies Mark R, Holden Matthew T, Coupland Paul, Chen Jonathan H K, Venturini Carola, Barnett Timothy C, Zakour Nouri L Ben, Tse Herman, Dougan Gordon, Yuen Kwok-Yung, Walker Mark J

Abstract excerpt

A scarlet fever outbreak began in mainland China and Hong Kong in 2011 (refs. 1-6). Macrolide- and tetracycline-resistant Streptococcus pyogenes emm12 isolates represent the majority of clinical cases. Recently, we identified two mobile genetic elements that were closely associated with emm12 outbreak isolates: the integrative and conjugative element ICE-emm12, encoding genes for tetracycline and macrolide...

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PMID: 25401300
DOI: 10.1038/ng.3147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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