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Article

Toward rational thermostabilization of Aspergillus oryzae cutinase: Insights into catalytic and structural stability.

Proteins - 1 Jan 2016

Shirke Abhijit N, Basore Danielle, Butterfoss Glenn L, Bonneau Richard, Bystroff Christopher, Gross Richard A

Abstract excerpt

Cutinases are powerful hydrolases that can cleave ester bonds of polyesters such as poly(ethylene terephthalate) (PET), opening up new options for enzymatic routes for polymer recycling and surface modification reactions. Cutinase from Aspergillus oryzae (AoC) is promising owing to the presence of an extended groove near the catalytic triad which is important for the orientation of polymeric chains. However, the...

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PMID: 26522152
DOI: 10.1002/prot.24955
PMCID: PMC4715774

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