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Article

In silico mutagenesis on active site residues of Acinetobacter haemolyticus lipase KV1 for improved binding to polyethylene terephthalate (PET).

Journal of biomolecular structure & dynamics - 1 Jan 2026

Khairul Anuar Nurul Fatin Syamimi, Abdul Wahab Roswanira, Huyop Fahrul, Normi Yahaya M, Oyewusi Habeebat Adekilekun, Susanti Evi

Abstract excerpt

Polyethylene terephthalate (PET) pollution is an emerging environmental hazard because of its recalcitrance to degradation. This study proposes an in silico mutagenesis of LipKV1 from Acinetobacter haemolyticus for improved lipase-PET interaction, using the PET-degrading Thermobifida cutinase (TfCut2) as the structural benchmark. Results revealed that lid deletion on LipKV1 (LipKV1_LE) facilitated the entry of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 39609936
DOI: 10.1080/07391102.2024.2431655

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