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Article

Impact of EGFR mutation on outcomes following SRS for brain metastases in non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 May 2021

Moraes Fabio Y, Mansouri Alireza, Dasgupta Archya, Ramotar Matthew, Kosyak Natalya, Weiss Jessica, Laperriere Normand, Millar Barbara-Ann, Berlin Alejandro, Conrad Tatiana, van Prooijen Monique, Heaton Robert, Coolens Catherine, Winter Jeff, Bernstein Mark, Zadeh Gelareh, Kongkham Paul, Doherty Mark, Shultz David B

Abstract excerpt

INTRODUCTION: Patients with EGFR-mutated (EGFRm) non-small cell lung cancer (NSCLC) are at particularly high risk of developing brain metastases (BrM). In addition to EGFR targeting tyrosine kinase inhibitors (TKI), radiosurgery (SRS) has an important role in the management of EGFRm BrM. However, data specific to the response and toxicity of EGFRm BrM to SRS are sparse. We evaluated the incidence of local failure...

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Identifiers

PMID: 33721614
DOI: 10.1016/j.lungcan.2021.02.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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