Article
TRIB1 constitutes a molecular link between regulation of sleep and lipid metabolism in humans.
Translational psychiatry - 20 Mar 2012
Ollila H M, Utge S, Kronholm E, Aho V, Van Leeuwen W, Silander K, Partonen T, Perola M, Kaprio J, Salomaa V, Sallinen M, Härmä M, Porkka-Heiskanen T, Paunio T
Abstract excerpt
Epidemiological studies show association between sleep duration and lipid metabolism. In addition, inactivation of circadian genes induces insulin resistance and hyperlipidemia. We hypothesized that sleep length and lipid metabolism are partially controlled by the same genes. We studied the association of total sleep time (TST) with 60 genetic variants that had previously been associated with lipids. The analyses...
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