Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High interleukin-4 expression and interleukin-4 gene polymorphisms are associated with susceptibility to human paracoccidioidomycosis.

Memorias do Instituto Oswaldo Cruz - 1 Sept 2015

Mendonça Mônica Sawan, Peraçolli Terezinha S, Silva-Vergara Mário León, Ribeiro Sílvio C, Oliveira Rafael Faria, Mendes Rinaldo Poncio, Rodrigues Virmondes

Abstract excerpt

Paracoccidioidomycosis (PCM) is caused by dimorphic fungi from the Paracoccidioides brasiliensis complex. Previous studies have demonstrated that the severity of disease is associated with a T-helper 2 immune response characterised by high interleukin (IL)-4 production. In the present study we analysed two polymorphisms in the IL-4 gene (-590 C/T and intron-3 microsatellite) in 76 patients with PCM and 73 control...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endemic Diseases
Share to Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-4

Share to Leukocytes, Mononuclear

Share to Microsatellite Repeats

Share to Promoter Regions, Genetic

Share to Statistics, Nonparametric

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 26517657
DOI: 10.1590/0074-02760150197
PMCID: PMC4667581

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High interleukin-4 expression and interleukin-4 gene polymorphisms are associated with susceptibility to human paracoccidioidomycosis.PMID 26517657Read ↗

Interferon-gamma and interleukin-4 single nucleotide gene polymorphisms in Paracoccidioidomycosis.Semantic proximity Read ↗

Genetic background and immune response in paracoccidioidomycosis: A systematic review and meta-analysis of single nucleotide variants.Semantic proximity Read ↗

Interleukin-10 and tumor necrosis factor-alpha single nucleotide gene polymorphism frequency in paracoccidioidomycosis.Semantic proximity Read ↗

Polymorphism in the Promoter Region of the IL18 Gene and the Association With Severity on ParacoccidioidomycosisSemantic proximity Read ↗

Polymorphism analysis of the CTLA-4 gene in paracoccidioidomycosis patients.Semantic proximity Read ↗

Polymorphisms on IFNG, IL12B and IL12RB1 genes and paracoccidioidomycosis in the Brazilian population.Semantic proximity Read ↗

PbGP43 Genotyping Using Paraffin-Embedded Biopsies of Human Paracoccidioidomycosis Reveals a Genetically Distinct Lineage in the Paracoccidioides brasiliensis Complex.Semantic proximity Read ↗

Functionality and opposite roles of two interleukin 4 haplotypes in immune cells.Semantic proximity Read ↗

Cytokine gene polymorphisms and susceptibility to cutaneous leishmaniasis in Iranian patients.Semantic proximity Read ↗

PbGP43 Genotyping Using Paraffin-embedded Biopsies of Human Paracoccidioidomycosis Reveals a Genetically Distinct Lineage in the Paracoccidioides Brasiliensis ComplexSemantic proximity Read ↗

Genetic variants of IL6 gene promoter influence on C-reactive protein levels but are not associated with susceptibility to invasive pulmonary aspergillosis in haematological patients.Semantic proximity Read ↗

Frequencies of the -330 (T --> G) IL-2 and -590 (T --> C) IL-4 gene polymorphisms in a population from south-eastern Brazil.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.