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Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer

29 Oct 2015

Abstract excerpt

Human papillomavirus (HPV) is the causative agent in cervical cancer. HPV oncogenes are major drivers of the transformed phenotype, and the cancers remain addicted to these oncogenes. A screen of the human kinome has identified inhibition of Aurora kinase A (AURKA) as being synthetically lethal on the background of HPV E7 expression. The investigational AURKA inhibitor MLN8237/Alisertib selectively promoted...

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PMID: 26516156
DOI: 10.1158/1535-7163.mct-15-0506

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