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Histone H3 lysine 27 trimethylation acts as an epigenetic barrier in porcine nuclear reprogramming

29 Oct 2015

Abstract excerpt

Aberrant epigenetic reprogramming is the main obstacle to the development of somatic cell nuclear transfer (SCNT) embryos and the generation of induced pluripotent stem (iPS) cells, which results in the low reprogramming efficiencies of SCNT and iPS. Histone H3 lysine 27 trimethylation (H3K27me3), as a repressive epigenetic mark, plays important roles in mammalian development and iPS induction. However, the...

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PMID: 26515777
DOI: 10.1530/rep-15-0338

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