Article
Fc Gamma Receptor 3A and 2A Polymorphisms Do Not Predict Response to Rituximab in Follicular Lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2016
Kenkre Vaishalee P, Hong Fangxin, Cerhan James R, Lewis Marcia, Sullivan Leslie, Williams Michael E, Gascoyne Randy D, Horning Sandra J, Kahl Brad S
Abstract excerpt
PURPOSE: Preclinical studies suggest that SNPs in the Fc gamma receptor (FCGR) genes influence response to rituximab, but the clinical relevance of this is uncertain. EXPERIMENTAL DESIGN: We prospectively obtained specimens for genotyping in the rituximab extended schedule or re-treatment trial (RESORT) study, in which 408 previously untreated, low tumor burden follicular lymphoma (FL) patients were treated with...
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