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Article

Impact of red blood cell alloimmunization on sickle cell disease mortality: a case series

28 Oct 2015

Abstract excerpt

BACKGROUND: Although red blood cell (RBC) transfusion represents an integral component of sickle cell disease (SCD) care, transfusion support for some patients can result in alloimmunization to RBC antigens. Alloimmunized patients with SCD appear to experience worse survival compared to nonalloimmunized patients. While this difference in mortality may in part be due to underlying immunologic differences related...

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PMID: 26509333
DOI: 10.1111/trf.13379

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