Alloimmunization in sickle cell anemia and transfusion of racially unmatched blood.

doi:10.1056/NEJM199006073222301

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Article

Alloimmunization in sickle cell anemia and transfusion of racially unmatched blood.

The New England journal of medicine - 7 Jun 1990

Vichinsky E P, Earles A, Johnson R A, Hoag M S, Williams A, Lubin B

Abstract excerpt

Transfusion therapy for sickle cell anemia is limited by the development of antibodies to foreign red cells. To evaluate the frequency and risk factors associated with such alloimmunization, we determined the transfusion history, red-cell phenotype, and development of alloantibodies in 107 black patients with sickle cell anemia who received transfusions. We compared the results with those from similar studies in...

Topics

Adolescent
Adult
Anemia
Anemia, Sickle Cell
Antibody Formation
Blood Donors
Blood Group Incompatibility
Blood Grouping and Crossmatching
Child
Child, Preschool
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infant

Isoantibodies

Phenotype

Prospective Studies

Racial Groups

Transfusion Reaction

Source

Open in PubMed

Identifiers

PMID: 2342522
DOI: 10.1056/NEJM199006073222301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2342522-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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