Transfusion and alloimmunization in sickle cell disease. The Cooperative Study of Sickle Cell Disease.

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Article

Transfusion and alloimmunization in sickle cell disease. The Cooperative Study of Sickle Cell Disease.

Blood - 1 Oct 1990

Rosse W F, Gallagher D, Kinney T R, Castro O, Dosik H, Moohr J, Wang W, Levy P S

Abstract excerpt

In 1,814 patients with sickle cell disease who had been transfused, the overall rate of alloimmunization to erythrocyte antigens was 18.6%. The rate of alloimmunization in this group appears to be an explicit function of the number of transfusions received because it increases exponentially with...

Topics

Adolescent
Adult
Age Factors
Anemia, Sickle Cell
Blood Transfusion
Child
Child, Preschool
Cross-Sectional Studies
Female
Hemoglobins
Humans
Immunity, Cellular
Immunization
Incidence
Isoantibodies
Isoantigens
Male
Phenotype

Source

Open in PubMed

Identifiers

PMID: 2207318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2207318-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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