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Article

Population-Level Human Secretor Status Is Associated With Genogroup 2 Type 4 Norovirus Predominance.

The Journal of infectious diseases - 11 May 2020

Arrouzet Cory J, Ellis Karen, Kambhampati Anita, Chen Yingxi, Steele Molly, Lopman Ben

Abstract excerpt

BACKGROUND: Noroviruses are a leading cause of acute gastroenteritis. Genogroup 2 type 4 (GII.4) has been the dominant norovirus genotype worldwide since its emergence in the mid-1990s. Individuals with a functional fucosyltransferase-2 gene, known as secretors, have increased susceptibility to GII.4 noroviruses. We hypothesized that this individual-level trait may drive GII.4 norovirus predominance at the human...

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Identifiers

PMID: 31900482
DOI: 10.1093/infdis/jiz693
PMCID: PMC7213563

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