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Article

Evaluation of regulatory genetic variants in POU5F1 and risk of congenital heart disease in Han Chinese.

Scientific reports - 28 Oct 2015

Lin Yuan, Ding Chenyue, Zhang Kai, Ni Bixian, Da Min, Hu Liang, Hu Yuanli, Xu Jing, Wang Xiaowei, Chen Yijiang, Mo Xuming, Cui Yugui, Shen Hongbing, Sha Jiahao, Liu Jiayin, Hu Zhibin

Abstract excerpt

OCT4 is a transcription factor of the POU family, which plays a key role in embryonic development and stem cell pluripotency. Previous studies have shown that Oct4 is required for cardiomyocyte differentiation in mice and its depletion could result in cardiac morphogenesis in embryo. However, whether the genetic variations in OCT4 coding gene, POU5F1, confer the predisposition to congenital heart disease (CHD) is...

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PMID: 26507003
DOI: 10.1038/srep15860
PMCID: PMC4623744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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