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Article

Identification and functional study of GATA4 gene regulatory variants in atrial septal defects.

BMC cardiovascular disorders - 30 Jun 2021

Fan Dongchen, Pang Shuchao, Chen Jing, Shan Jiping, Cheng Qianjin, Yan Bo

Abstract excerpt

BACKGROUND: Congenital heart disease (CHD) is the leading cause of mortality from birth defects. In adult CHD patients with successful surgical repair, cardiac complications including heart failure develop at late stage, likely due to genetic causes. To date, many mutations in cardiac developmental genes have been associated with CHD. Recently, regulatory variants in genes have been linked to many human diseases....

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Identifiers

PMID: 34193080
DOI: 10.1186/s12872-021-02136-w
PMCID: PMC8243876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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