BIT: Bayesian Identification of Transcriptional Regulators from Epigenomics-Based Query Region Sets

Abstract excerpt

Transcriptional regulators (TRs) are master controllers of gene expression and play a critical role in both normal tissue development and disease progression. However, existing computational methods for identification of TRs regulating specific biological processes have significant limitations, such as relying on distance on a linear chromosome or binding motifs that have low specificity. Many also use statistical...

Topics

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• Algorithms
• Gene Expression
• Gene Regulatory Networks
• Genomics
• Models, Statistical
• Stress, Physiological
• Transcription Factors
• Yeasts

Identifiers and source

Literature Corpus work

11771b48-4610-5639-88bc-00219ca8bc68

DOI

10.1101/2024.06.02.597061