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Article

The Possible Involvement of HLA Class III Haplotype (RAGE, HSP70 and TNF Genes) in Alzheimer's Disease.

Current Alzheimer research - 1 Jan 2015

Boiocchi Chiara, Maggioli Elisa, Monti Maria Cristina, Zorzetto Michele, Sinforiani Elena, Cereda Cristina, Ricevuti Giovanni, Cuccia Mariaclara

Abstract excerpt

In the central nervous system Hsp70s seems to have a protective role in repair and removal of cellular proteins damaged by stress conditions. A protective role of Hsp70 was also shown in Alzheimer Disease. The HSP70-1 +190 G/C polymorphism is located in the gene 5'UTR region and it is implicated in alteration of the transcription binding factor; HSP70-2 +1267 A/G causes a silent mutation in the coding region and...

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PMID: 26502815
DOI: 10.2174/1567205012666151027130635

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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