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Article

IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide.

Oncotarget - 24 Nov 2015

Ramcharan Roger, Aleksic Tamara, Kamdoum Wilfride Petnga, Gao Shan, Pfister Sophia X, Tanner Jordan, Bridges Esther, Asher Ruth, Watson Amanda J, Margison Geoffrey P, Woodcock Mick, Repapi Emmanouela, Li Ji-Liang, Middleton Mark R, Macaulay Valentine M

Abstract excerpt

Prior studies implicate type 1 IGF receptor (IGF-1R) in mediating chemo-resistance. Here, we investigated whether IGF-1R influences response to temozolomide (TMZ), which generates DNA adducts that are removed by O6-methylguanine-DNA methyltransferase (MGMT), or persist causing replication-associated double-strand breaks (DSBs). Initial assessment in 10 melanoma cell lines revealed that TMZ resistance correlated...

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Identifiers

PMID: 26497996
DOI: 10.18632/oncotarget.5631
PMCID: PMC4741867

Genes

MGMT
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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