Article
Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology.
BMC cancer - 23 Oct 2015
Poynter Jenny N, Bestrashniy Jessica R B M, Silverstein Kevin A T, Hooten Anthony J, Lees Christopher, Ross Julie A, Tolar Jakub
Abstract excerpt
BACKGROUND: Alterations in methylation patterns, miRNA expression, and stem cell protein expression occur in germ cell tumors (GCTs). Our goal is to integrate molecular data across platforms to identify molecular signatures in the three main histologic subtypes of Type I and Type II GCTs (yolk sac tumor (YST), germinoma, and teratoma). METHODS: We included 39 GCTs and 7 paired adjacent tissue samples in the...
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