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Pan‐cancer analysis of TIM ‐3 transcriptomic expression reveals high levels in pancreatic cancer and interpatient heterogeneity

22 Dec 2023

Abstract excerpt

BACKGROUND: T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), an immune checkpoint receptor, dampens immune function. TIM-3 antagonists have entered the clinic. METHODS: We analyzed TIM-3 transcriptomic expression in 514 diverse cancers. Transcript abundance was normalized to internal housekeeping genes and ranked (0-100 percentile) to a reference population (735 tumors; 35 histologies [high≥75...

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PMID: 38132831
DOI: 10.1002/cam4.6844

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