Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of ABCC8 as a contributory gene to impaired early-phase insulin secretion in NZO mice.

The Journal of endocrinology - 1 Jan 2016

Andrikopoulos Sofianos, Fam Barbara C, Holdsworth Anita, Visinoni Sherley, Ruan Zheng, Stathopoulos Maria, Thorburn Anne W, Joannides Christos N, Cancilla Michael, Balmer Lois, Proietto Joseph, Morahan Grant

Abstract excerpt

Type 2 diabetes (T2D) is associated with defective insulin secretion, which in turn contributes to worsening glycaemic control and disease progression. The genetic cause(s) associated with impaired insulin secretion in T2D are not well elucidated. Here we used the polygenic New Zealand Obese (NZO) mouse model, which displays all the cardinal features of T2D including hyperglycaemia to identify genes associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to Glucose Intolerance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose Tolerance Test

Share to Insulin-Secreting Cells

Share to Insulin Secretion

Share to Mice, Obese

Share to Potassium Channels, Inwardly Rectifying

Share to Sulfonylurea Receptors

Source

Identifiers

PMID: 26493453
DOI: 10.1530/JOE-15-0290

Genes

ABCC8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of ABCC8 as a contributory gene to impaired early-phase insulin secretion in NZO mice.PMID 26493453Read ↗

Genome-edited zebrafish model of <i>ABCC8</i> loss-of-function diseaseSemantic proximity Read ↗

Pathophysiology and genetics of obesity and diabetes in the New Zealand obese mouse: a model of the human metabolic syndrome.Semantic proximity Read ↗

ABCC8 genetic variants and risk of diabetes mellitus.Semantic proximity Read ↗

Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action.Semantic proximity Read ↗

Clinical and Genetic Characteristics of ABCC8 Nonneonatal Diabetes Mellitus: A Systematic Review.Semantic proximity Read ↗

ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes.Semantic proximity Read ↗

Sur1 Knockout MiceSemantic proximity Read ↗

Direct evidence for susceptibility genes for type 2 diabetes on mouse chromosomes 11 and 14.Semantic proximity Read ↗

ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm?Semantic proximity Read ↗

Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic (Type 2) Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8.Semantic proximity Read ↗

E96V Mutation in the Kdelr3 Gene Is Associated with Type 2 Diabetes Susceptibility in Obese NZO Mice.Semantic proximity Read ↗

Targeting SUR1/Abcc8-type neuroendocrine KATP channels in pancreatic islet cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.