Genomic Landscape of CXCR4 Mutations in Waldenström Macroglobulinemia.

doi:10.1158/1078-0432.CCR-15-0646

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Article

Genomic Landscape of CXCR4 Mutations in Waldenström Macroglobulinemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2016

Poulain Stéphanie, Roumier Christophe, Venet-Caillault Aurélie, Figeac Martin, Herbaux Charles, Marot Guillemette, Doye Emmanuelle, Bertrand Elisabeth, Geffroy Sandrine, Lepretre Frédéric, Nibourel Olivier, Decambron Audrey, Boyle Eileen Mary, Renneville Aline, Tricot Sabine, Daudignon Agnès, Quesnel Bruno, Duthilleul Patrick, Preudhomme Claude, Leleu Xavier

Abstract excerpt

PURPOSE: Whole-genome sequencing has revealed MYD88 L265P and CXCR4 mutations (CXCR4(mut)) as the most prevalent somatic mutations in Waldenström macroglobulinemia. CXCR4 mutation has proved to be of critical importance in Waldenström macroglobulinemia, in part due to its role as a mechanism of resistance to several agents. We have therefore sought to unravel the different aspects of CXCR4 mutations in...

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Identifiers

PMID: 26490317
DOI: 10.1158/1078-0432.CCR-15-0646

Genes

CXCR4
BCR
MYD88

Variants

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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