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The adherens junctions control susceptibility to Staphylococcus aureus α-toxin

21 Oct 2015

Abstract excerpt

Staphylococcus aureus is both a transient skin colonizer and a formidable human pathogen, ranking among the leading causes of skin and soft tissue infections as well as severe pneumonia. The secreted bacterial α-toxin is essential for S. aureus virulence in these epithelial diseases. To discover host cellular factors required for α-toxin cytotoxicity, we conducted a genetic screen using mutagenized haploid human...

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Share to Antimicrobial Peptides and Activities
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PMID: 26489655
DOI: 10.1073/pnas.1510265112

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