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Article

Staphylococcus aureus protein A mediates invasion across airway epithelial cells through activation of RhoA GTPase signaling and proteolytic activity.

The Journal of biological chemistry - 14 Oct 2011

Soong Grace, Martin Francis J, Chun Jarin, Cohen Taylor S, Ahn Danielle S, Prince Alice

Abstract excerpt

Staphyococcus aureus and especially the epidemic methicillin-resistant S. aureus strains cause severe necrotizing pneumonia. The mechanisms whereby these organisms invade across the mucosal epithelial barrier to initiate invasive infection are not well understood. Protein A (SpA), a highly conserved and abundant surface protein of S. aureus, activates TNF receptor 1 and EGF receptor (EGFR) signaling cascades that...

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Identifiers

PMID: 21878647
DOI: 10.1074/jbc.M111.295386
PMCID: PMC3195615

Genes

EGFR
EGF
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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