Article
Utility of BRAF V600E mutation-specific immunohistochemistry in detecting BRAF V600E-mutated gastrointestinal stromal tumors.
American journal of clinical pathology - 1 Nov 2015
Patil Deepa T, Ma Shuang, Konishi Mai, Carver Paula D, Pukay Marina, Beadling Carol, Corless Christopher L, Rubin Brian P
Abstract excerpt
OBJECTIVES: As patients with BRAF V600E mutation respond to BRAF inhibitors, it is important to identify these mutations to stratify patients for the appropriate therapy. In this study, we evaluated the utility of a BRAF V600E allele-specific antibody in gastrointestinal stromal tumors (GISTs). METHODS: BRAF V600E mutation-specific immunohistochemistry (negative, weak, or moderate/strong expression) and BRAF...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.