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Unclassifiable CNS tumors in DNA methylation-based classification: clinical challenges and prognostic impact

16 Jan 2024

Abstract excerpt

DNA methylation analysis has become a powerful tool in neuropathology. Although DNA methylation-based classification usually shows high accuracy, certain samples cannot be classified and remain clinically challenging. We aimed to gain insight into these cases from a clinical perspective. To address, central nervous system (CNS) tumors were subjected to DNA methylation profiling and classified according to their...

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PMID: 38229158
DOI: 10.1186/s40478-024-01728-9

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